• Atrial fibrillation, venous thromboembolism, ischemic stroke, and all-cause mortality: The Tromsø study 

      Hald, Erin Mathiesen; Løchen, Maja-Lisa; Mathiesen, Ellisiv B; Wilsgaard, Tom; Njølstad, Inger; Brækkan, Sigrid K.; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-06)
      Background Atrial fibrillation (AF) is associated with increased risk of ischemic stroke and all‐cause mortality. Patients with AF are also at increased risk of venous thromboembolism (VTE), but information on how AF impacts VTE‐related mortality is scarce. Objectives - To investigate the impact of AF on all‐cause mortality in subjects with and without a thromboembolic event (VTE or ischemic ...
    • Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study-the Tromsø Study 

      Wilsgaard, Tom; Vangen-Lønne, Anne Merete; Mathiesen, Ellisiv B; Løchen, Maja-Lisa; Njølstad, Inger; Heiss, Gerardo; Danaei, Goodarz (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-24)
      <i>Objectives</i> - The aim of this study was to use the parametric g-formula to estimate the 19-year risk of myocardial infarction (MI) under hypothetical interventions on six cardiovascular risk factors. <p> <p><i>Design and setting</i> - A populations-based cohort study with repeated measurements, the Tromsø Study. <p> <p><i>Primary outcome measure</i> - Myocardial infarction. <p> <p>< ...
    • An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study 

      Hindenes, Lars Bakke; Håberg, Asta Kristine; Mathiesen, Ellisiv B; Vangberg, Torgil Riise (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)
      <p><i>Objective - </i>The Circle of Willis (CoW) is often underdeveloped or incomplete, leading to suboptimal blood supply to the brain. As hypoperfusion is thought to play a role in the aetiology of white matter hyperintensities (WMH), the objective of this study was to assess whether incomplete CoW variants were associated with increased WMH volumes compared to the complete CoW. <p><i>Methods - ...
    • Safety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial. 

      Roaldsen, Melinda Berg; Eltoft, Agnethe; Wilsgaard, Tom; Christensen, Hanne; Engelter, Stefan T.; Indredavik, Bent; Jatužis, Dalius; Karelis, Guntis; Kõrv, Janika; Lundström, Erik; Petersson, Jesper; Putaala, Jukka; Søyland, Mary-Helen; Tveiten, Arnstein; Bivard, Andrew; Johnsen, Stein Harald; Mazya, Michael; Werring, David J; Wu, Teddy Y; de Marchis, Gian Marco; Robinson, Thompson G; Mathiesen, Ellisiv B (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-19)
      Background - Current evidence supports the use of intravenous thrombolysis with alteplase in patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in clinical guidelines. However, access to advanced imaging techniques is often scarce. We aimed to determine whether thrombolytic treatment with intravenous tenecteplase given within 4·5 h of awakening improves functional ...
    • Sex-Specific Associations between Blood Pressure and Risk of Atrial Fibrillation Subtypes in the Tromsø Study 

      Espnes, Hilde; Ball, Jocasta; Løchen, Maja-Lisa; Wilsgaard, Tom; Njølstad, Inger; Mathiesen, Ellisiv B; Gerdts, Eva; Sharashova, Ekaterina (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-05)
      The aim of this study was to explore sex-specific associations between systolic blood pressure (SBP), hypertension, and the risk of incident atrial fibrillation (AF) subtypes, including paroxysmal, persistent, and permanent AF, in a general population. A total of 13,137 women and 11,667 men who participated in the fourth survey of the Tromsø Study (1994–1995) were followed up for incident AF until ...